بررسی ارتباط پلی‌مورفیسم 48 جفت بازی از ژن DRD4 با اختلال نارسایی توجه / بیش‌فعالی در کودکان مبتلا در شمال غرب ایران

Introduction: Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder that has defined by hyperactivity, impulsivity and attention deficits. Various neurotransmitters such as dopamine can play a role in its pathophysiology. The aim of this study was to examine the association of two common single nucleotid polymorphisms in DRD4 gene, a 48 bp VNTR polymorphism, with attention deficit hyperactivity disorder risk among Iranian-Azeri population. Materials and methods: case&ndash;control study was performed on 50 children with attention deficit hyperactivity disorder and 50 healthy ones. Peripheral blood samples were used for Genomic DNA extraction by proteinase K method. The collected data were analyzed through chi-square test (x2), with a significance level of 0.05. Results: considering the obtained results, there was a significant increase in 4/8 genotype frequency between two groups (p<0.05). Although, there was no significant difference in the allele and genotype frequencies in other genotypes between cases and controls (p>0.05). Conclusion: Our data confirmed the relationship between polymorphism of DRD4 and ADHD. Further studies with larger population of other groups will be required to explain the relationship between DRD4 polymorphism and the risk of ADHD